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Among these, the inactivation of GPX4a crucial inhibitor of ferroptosisplays a significant role in the pathogenesis of myocardial injury in DCM

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The first active site catalyzes the release of the amide nitrogen from glutamine as an ammonium ion, which enters the tunnel and reaches the second active site, where it is combined with bicarbonate, at the expense of ATP, to yield carbamate
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Conversely, feeding of bile acids profoundly suppresses the new synthesis of bile acids by hepatocytes