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Metformin is recommended as first-line pharmacological treatment for adults with type 2 diabetes, alongside lifestyle interventions including dietary modification and increased physical activity

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Before the federal reclamation era began in the early 1900s, canal builders in Tucson had begun digging wells and installing pumps near the heads of their canals so as to augment the modest supply of surface water.[115] This reliance on groundwater became the norm for Tucson farmers, while a reliance on surface water and damped canals became the pattern in Phoenix