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The effect was also associated with mitochondria, where CYP3A4 promoted the activity of the electron transport chain and increased oxidative phosphorylation

Figure 1 Preclinical studies treating primarily diabetic rodents with aldose reductase inhibitors demonstrated improvement in multiple endpoints associated with DPN ( + /K + ATPase activity ( + /K + ATPase is important for maintaining the sodium and potassium transmembrane potential that is required for nerve impulse conduction as well as the sodium gradient used for uptake of substrates that are Na + -dependent ( + -ATPase activity was also corrected as was DPN as determined by measurement of nerve conduction velocity

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