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Erwin WM, Islam D, Inman RD, Fehlings MG, Tsui FW: Notochordal cells protect nucleus pulposus cells from degradation and apoptosis: implications for the mechanisms of intervertebral disc degeneration

If 10 mg produces excellent efficacy but borderline intolerable nausea, try 7.5 mg for 6 to 8 weeks to assess whether efficacy remains adequate with improved tolerability

Within the CNS, PACAP is expressed primarily by nuclei of the brainstem, hypothalamus and thalamus, amygdala, cerebral cortex, medulla oblongata, and posterior pituitary as a 178-amino acid preprohormone

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