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When repair falls short, tissue integrity is still at least initially maintained by independent stress-response mechanisms as apoptosis and cellular senescence(de Keizer, 2017)
J Med Chem 62:1078310797
GSTT1 and GSTM1 polymorphisms predict treatment outcome for acute myeloid leukemia: A systematic review and meta-analysis
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As will be discussed, one mechanism which may connect thiol-metal binding to oxidative stress-mediated toxicity is specific of Hg, the cysteinyl-glycine bound form of which is able to deplete glutathione reservoirs by a catalytic process [34]
