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While it is intuitively assumed that antioxidants emerged during the GOE to defend against O 2 reactivity and toxicity caused by the accelerated oxygenation of the atmosphere, sequencing and phylogenetic analyses of antioxidant systems from ancient organisms suggests that antioxidant enzymes including SODs may have originated long before the surge of atmospheric and oceanic O 2 (Wolfe-Simon et al

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The PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta-Analyses of Health Care Interventions: Checklist and Explanations

Studies have shown that oxidative damage to the APC gene and activation of Wnt signaling, as a result of increased ROS levels, are key contributors to colorectal cancer pathogenesis [102]