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These findings suggest that ALOX12 depletion causes aberrant ROs

Mol.Genet.Metab 2008;94(3):287-291

Mod Pathol 14:733-737

As a revitalizing antioxidant, ALA helps fight a wide array of free radicals in the body

Mechanistically, this CSK-dependent pathogenesis of DSS-induced colitis involves activation of Src in the absence of CSK, which followed by the phosphorylation and subsequent proteasomal degradation of occludin, leads to the increased intercellular permeability of the IECs (Samak et al., 2015
