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The most specific site for culture is at the introitus, just inside the hymenal ring and rectally beyond the sphincter
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That is an attempt to move the discussion away from lots of doctors use this and toward a more surveillance-like question: how much exposure has actually occurred, across what timespan, and with what signal profile

However, its important to note that many doctors rule out B12 deficiency in earlier stages when macrocytosis is absent

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