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Yet, when someone with B12 deficiency reports that symptoms re-occur 4-5 weeks after a B12 injection, and wants to inject more often, all of a sudden, this person is mislabelled as suffering from the placebo effect of B12 injections
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When NNMT is overactive in adipocytes, SAM is depleted reducing the cells capacity for methylation reactions that regulate gene expression, including the epigenetic programs that control energy expenditure
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