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doi: 10.1074/jbc.272.24.15045 55 TeixeiraCStangSLZhengYBeswickNSStoneJC

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In the liver, a class of hepatic flavin monooxygenase (FMO) enzymes, predominantly FMO3, causes the oxidation of TMA to TMAO [21]

"Worse, current pharmacological treatments are effective for only about 50 percent of the people for whom they're prescribed
