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Table 4: Reasons to use medication to lower uric acid Gout with more than two flares a year, whether due to overproduction of uric acid or difficulty excreting it Chronic visible collections of uric acid (tophi) High uric acid in the urine (over 800mg per 24 hours), especially if history of kidney stone Failure of other options to control the arthritis of gout (for example, failure of probenecid) When a person is receiving chemotherapy for a leukemia or a lymphoma and it is expected that many tumor cells will be killed (since one of the breakdown products of cells is purine which gets broken down to uric acid) iii

If you suspect air has entered the cartridge (after a temperature change or rough handling), prime again before your next injection

The lethal dose threshold (LD1) was never achieved in animal safety studies meaning researchers could not identify a dose lethal to 1% of test subjects

non-injecting opioid participants over time (maintenance doses) with propensity weighting that balances risk factors between maintenance dosage groups, which addresses an earlier limitation

Now that we understand what each type is, let's see how they compare