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3.4.6 Antioxidant system The activation of a robust and complex antioxidant system is the reaction mechanism of the symbiotic system to environmental stress, including non-enzymatic antioxidants (glutathione, betaine, proline, and ascorbic acid) and antioxidant enzymes (Wang J

this molecular cascade ultimately strengthens cellular antioxidant defenses (Zhang et al., 2024a)

J Clin Endocrinol Metab 33(3):382387 [DOI] [PubMed] [Google Scholar] Sahpazidou D, Geromichalos GD, Stagos D, Apostolou A, Haroutounian SA, Tsatsakis AM, Tzanakakis GN, Hayes AW, Kouretas D (2014) Anticarcinogenic activity of polyphenolic extracts from grape stems against breast, colon, renal and thyroid cancer cells

In addition, both the enzymes involved in the gluconeogenesis oxaloacetate workaround use manganese as cofactors as shown below

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