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We will discuss the underlying mechanisms of cellular senescence, the progress in developing senolytics and senomorphics, and the preclinical and clinical data supporting their potential as therapeutic agents

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In renal failure, perturbed intestinal microorganisms produce several metabolic products that can have an influence on the kidneys, including indoxyl sulfate, trimethylamine N-oxide, phenylacetylglutamine, and p-cresyl sulfate