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Additionally, the interindividual variability in gut microbiota composition significantly influences polyphenol biotransformation into bioactive metabolites, complicating the prediction of therapeutic outcomes and impeding the standardization of treatments (Cardona et al

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Preclinical data from the University of Arizona showed maximal receptor occupancy at 10^-9 M concentrations in cortical neuron cultures, with no additional signaling observed when concentrations increased tenfold

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