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10.1016/j.ccell.2020.06.001 86 HeijmansM.HabetsJ
KaplanMeier survival analysis revealed that the IGH group exhibited significantly poorer survival outcomes compared to the IGL group, suggesting that GSH may contribute to neoadjuvant chemotherapy resistance and lead to a worse prognosis in breast cancer patients

TME is a complex ecosystem composed of tumor cells, extracellular matrix (ECM), innate and adaptive immune cells, inflammatory cells, tumor-associated macrophages (TAMs), cancer-associated fibroblasts (CAFs), tumor-associated neutrophils, myeloid-derived suppressor cells (MDSCs), endothelial cells, microvascular networks, as well as various cytokines and chemokines (Wu et al., 2022)

This method could confirm the stability of the target protein in a complex with the candidate ligands and determine the stability and rigidity of proteinligand complexes in a specific artificial environment, such as the body [32]
