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This uncertainty represents a significant limitation

Archived from the original on December 8, 2024

All three domains bind the HCV 3 UTR 17 : DI functions in both genome replication and virus assembly 18,19 , DII is exclusively involved in genome replication 20 and DIII plays a critical role in virion assembly 21

coli bacteria, we cloned the coding sequence of ifc-2e into the NheI/BamHI sites of plasmid pET24a(+) (Merck, Darmstadt, Germany, #69749) giving rise to plasmid pIFC-2e (#1856)

It remains to be clarified if the impaired removal of TRLs and their remnants is mainly due to reduced lipolytic capacity or to reduced hepatic removal of TRL remnants