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Endogenous (e.g., inflammation) and exogenous (e.g., diet components, toxicants, or drugs) factors can increase intestinal permeability and cause the formation of a so-called leaky gut. The latter is characterized by the penetration of food antigens, commensals, or pathogenic bacteria into the blood, causing the development of inflammation (Vanuytsel et al., 2021)

The human body processes APAP via three primary pathways (Fig

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FIGURE 1 Alcohol-Oxidative Stress-Induced Mitochondrial Apoptosis Oxidative stress refers to an imbalance of the redox system characterized by excessive level of free radicals and impaired antioxidant system