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Once the vial is first punctured, the risk of contamination increases, and additional precautions may be necessary

doi: 10.1159/000471813

Journal of Neuroscience Research, 91(10), 1296-1305

Other stressors such as emotional stress or dehydration also disrupt healthy circulation causing dark circles under the eyes

Some patients experience mild injection-site soreness, temporary warmth, or a brief metallic taste