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Apart from -synuclein, Lewy bodies also contain many other aggregated cellular proteins, which together constitute an interactome to promote fibrillation of -synuclein ( Under normal physiological conditions -synuclein exists mostly in an N acetylated membrane bound form which results in adoption of an -helical structure (Runfola et al., 2020)

Phytomedicine 110, 154651

OH can react with metals like Fe (already present in the cytosol) to start a chain of oxidation reaction and the subsequent generation of ROS, resulting from the Fenton reaction, leads to cellular damage (Hasan et al., 2024)

JAMA 328 (20), 2078

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