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Some of protective substances have the ability to reduce BaP metabolism, and in particular reduce the induction of cytochrome (CYP P450), which reduces the formation of oxidative metabolites, and therefore decreases ROS production
In addition, hypoxia represents an inhibitory signal for GSH synthesis, since it decreases the activity of the two key biosynthetic enzymes GCL and GS [13]
Medications: Low-dose ACE inhibitor for BP, statin for vascular support
Antioxidant Defense : By neutralizing free radicals, glutathione protects cells from oxidative stress and damage
