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However, long-term human studies specifically examining extended use remain limited

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A 2026 retrospective population study of 84 million B12 measurements showed a 32 % increase in B12 deficiency-linked hospitalizations from 2016 to 2023

Education into practice Practice How often do you evaluate B 12 deficiency related symptoms in individuals at high risk of developing this, such as vegetarians and vegans, or people with increased risk of B 12 malabsorption, such as individuals with type 1 diabetes or Hashimoto hypothyroidism

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