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While it is better studied in skin and wound healing contexts, there is emerging preclinical data suggesting GHK-Cu supports extracellular matrix remodeling and anti-inflammatory gene expression in gut tissue

PLoS ONE 5 , e15545 (2010)

However, since GSR activity increases in response to rising GSSG levels during oxidative stress, it is possible that significant increases in GSR activity are a characteristic of tissue in acute oxidative stress rather than a constitutive measure (Jones, 2002)

Endogenous enzymes and proteins can be covalently modified through oxidative modification or carbonylation, leading to protein dysfunction, impaired cell function, and contributing to the etiology of various human diseases [53,59,60,61,62]

[DOI] [PubMed] [Google Scholar] 242.Treadwell T., Kleinman H.K., Crockford D., Hardy M.A., Guarnera G.T., Goldstein A.L